Thursday, March 19, 9:00 am - 11:00 am

Cannabis, Anxiety,and Depression: Cause for Pause or Peace of Mind?

presented by: Staci Gruber, PhD

During this presentation, Dr. Gruber will summarize the complex the relationship between cannabis use and anxiety and depression, and will discuss how important differences between recreational users and medical cannabis (MC) patients may impact this relationship. She will present recent findings from the cannabis Investigations for Neuroscientific Discovery (MIND) program, including data from the first longitudinal study of MC patients, which reflect changes on measures of cognitive function, clinical state, quality of life, conventional medication use, and neuroimaging variables after initiation of MC treatment. She will also highlight preliminary data from the first clinical trial of a plant-derived, full-spectrum, high-cannabidiol (CBD) product for the treatment of anxiety. Finally, she will explain potential reasons for the changes observed in these studies and highlight areas in need of future research.

Learning Objectives:

  • Understand important distinctions between medical cannabis patients and recreational cannabis users 
  • Summarize findings from studies assessing the cannabinoids and anxiety
  • Identify changes exhibited by medical cannabis (MC) patients after three months of MC treatment
  • Explain potential reasons for the changes observed after initiation of MC treatment

Dr. Staci Gruber is the Director of the Cognitive and Clinical Neuroimaging Core at McLean Hospital’s Brain Imaging Center and an Associate Professor of Psychiatry at Harvard Medical School. Dr. Gruber’s clinical research focuses on the application of neurocognitive models and brain imaging to better characterize risk factors for substance abuse and psychiatric conditions. She has been studying the impact of marijuana on the brain for over two decades using neurocognitive, clinical and diagnostic assessments and multimodal brain imaging techniques. 

Her work examining the etiologic bases of neural models of dysfunction in marijuana-using adolescents and adults has been published in numerous peer reviewed journals and been the basis of national and international symposia, documentaries, news stories and press conferences. Her ongoing initiative to educate policymakers, judges, attorneys and the general public about the neurobiologic differences between adults and adolescents as well as additional factors that contribute to the impact of marijuana on the brain have had both local and national impact on policy formation. 

Dr. Gruber recognized the importance of examining the impact of medical marijuana use on the brain, as there are many inherent differences between recreational and medical marijuana users. Accordingly, in 2014, Dr. Gruber launched Marijuana Investigations for Neuroscientific Discovery (MIND), the first ever program of its kind designed to clarify the specific effects of medical marijuana use. MIND utilizes valid, robust research models and supports numerous projects designed to address the impact of medical marijuana on a number of important variables including cognition, brain structure and function, clinical state, conventional medication use, quality of life, pain, sleep, and other health-related measures. As the director of MIND, Dr. Gruber has generated major contributions to the field as the first to assess medical marijuana patients longitudinally and to acquire neuroimaging data in medical marijuana patients. She is also the Principal Investigator of the first ever clinical trial of a whole plant-derived, high CBD product specifically formulated to treat anxiety, and has a number of other clinical projects in progress or pending.

Medical Marijuana: The Evidence and Promises of CBD

presented by Diana Martinez, MD

Dr. Martinez will summarize the literature on cannabis for medical disorders, with a focus on placebo controlled, prospective studies. This will include research on cannabis plant extract, delta (9)-tetrahydrocannabinol (and congeners), and cannabidiol. She will also review the observational studies showing the risks of recreational cannabis use in medically ill patients. A brief discussion on the use of cannabis plant extract in neuropathy and pain will also be included.

Dr. Diana Martinez is a Professor of Psychiatry at the Columbia University Medical Center. She is originally from Texas and went to college in Santa Fe, NM, where she studied philosophy. She moved to New York City to attend medical school, at Cornell University, and performed her third-year surgical rotation at Lennox Hill hospital. After that, she decided to become a psychiatrist and completed residency at New York Hospital.

Most of her research career has focused on imaging the neurochemistry of addiction and understanding the neuroscience behind compulsive drug use. More recently, her research has moved into repurposing drugs to treat refractory disorders, such as ketamine to treat tinnitus and cannabis for neuropathy caused by chemotherapy. The overarching goal is to perform studies that can directly translate into clinical care.


Learning Objectives:

  • Understanding the medical conditions that have sufficient research behind them to support the use of cannabis. This includes studies using standardized statistical methods and metanalyses.
  • The medical conditions that require caution when using cannabis as a medication, such as heat disease and psychiatric disorders.
  • The caveats and pitfalls of using cannabidiol (CBD) for medical purposes.