RDoC and Mood & Anxiety Disorders: Recent Advances and Future Directions

Saturday, April 7
8:00 am - 12:00 pm

(Supported by an educational grant from Janssen Research & Development, LLC)

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Syndromes of dysregulated affect, like anxiety and depressive disorders, are common, debilitating conditions with poorly understood patho-etiology. While evolving formulations of DSM have described them with increasing specificity and reliability of symptomatic criteria, a growing body of basic research has suggested that these conditions share more of their risk factor domains and underlying neurobiology than would be predicted by clinical nosology alone. In 2009, the National Institute of Mental Health launched the Research Domain Criteria (RDoC) initiative, calling for a new approach to understanding psychiatric disorders based on psychological constructs, dimensions of observable behavior, and neurobiological measures. RDoC aims to serve as a framework for new approaches to research on mental disorders using fundamental dimensions that cut across traditional disorder categories and align with mechanisms that underlie psychopathology at various biological levels from genes to neural circuits. This symposium brings together experts spanning the spectrum from RDoC program staff to basic/translational scientists to clinical investigators. These presenters will highlight how RDoC is influencing ongoing mood/anxiety clinical research and practice using study designs ranging from precise neuroimaging and genetics approaches to electronic health record and case analysis.

Learning Objective 1: Attendees will recognize psychological constructs proposed under the RDoC Negative Valence System, Positive Valence System, and Systems for Social Processes domains.

Learning Objective 2: Attendees will compare different study designs for investigating key questions about RDoC domains related to anxiety and depression.

Learning Objective 3: Attendees will apply RDoC-inspired investigative approaches in their own research and clinical practice.


PINE_0.jpgDaniel Pine, MD
Chief, Development and Affective Neuroscience Unit
National Institute of Mental Health (NIMH)

NIMH Scientific Perspective

Deanna-Barch_0_0.jpgDeanna Barch, PhD
Professor of Psychological & Brain Sciences
Washington University-St. Louis

Understanding risk for mood pathology from an RDoC Perspective: Motivation, Emotion Regulation and Cognitive Control

Joel-Yager.jpgJoel Yager, MD
University of Colorado-Denver Psychiatry Department

Clinical Research and Clinical Application Perspective

JanineSimmons_200_0.jpgJanine M. Simmons, MD, PhD 
Program Chief
National Institute for Mental Health (NIMH)

The NIMH Research Domain Criteria Initiative: A new framework for studying psychiatric disorders

Roy Perlis.jpgRoy Perlis, MD
Harvard Psychiatry Department

Clinical Research and Application



Hettema_0.jpgJohn M. (Jack) Hettema, MD, PhD
Virginia Commonwealth University




Andrew-Goddard_0.jpgAndrew W. Goddard, MD
University of California San Francisco