Morning Light Treatment for Traumatic Stress: The Role of Amygdala Reactivity

 IRB Registration Number(s): IRB00000244

This is a study evaluating the association between increasing duration of morning light treatment and the degree of change in amygdala reactivity to an emotional faces fMRI task in individuals with a history of traumatic stress. Participants will be randomized to receive 15/30/60-minutes per day of morning light treatment. Amygdala reactivity (via fMRI) and mood and traumatic stress symptoms will be assessed at baseline, after 2 weeks of treatment and after 4 weeks of treatment. In total, participants will be in the study for approximately 5 weeks: a week of baseline plus 4 weeks of treatment. Participants will be monitored via weekly visits for protocol adherence and treatment side effects.

Organization
The University of Michigan
Principal Investigator
Alyson K. Zalta
Eligibility Criteria

Inclusion Criteria:

  • Meets criteria for traumatic stress
  • Normal or corrected to normal vision
  • Right-handed
  • Fluency in English
  • Physically able to travel for study visit attendance
Exclusion Criteria

Exclusion Criteria:

  • Significant chronic uncontrolled disease (e.g. uncontrolled diabetes, advanced liver disease, cancer, etc.)
  • Severe hearing problem
  • Intellectual disability or serious cognitive impairment
  • Inability to tolerate enclosed spaces (e.g. the MRI machine)
  • Ferrous-containing metals within the body
  • Pregnant, trying to get pregnant, or breastfeeding
  • Epilepsy
  • Other research participation
  • Frequent number of special events during study period (weddings, concerts, exams, etc.)
Contact
Location
The University of Michigan; Ann Arbor, Michigan, United States, 48109
State
MI
Study End Date

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