We are currently enrolling individuals with significant and distressing body image concerns (e.g., concerns about skin, hair, nose) to participate in a research study that will assess whether a single dose of psilocybin may be a safe and effective treatment to improve appearance -related worries. For eligible participants, the research study will involve 1 visit that is around 8 hours during which they will receive psilocybin with the support of a therapist. Participants will then return for follow-up visits over the course of 12 weeks. The study will also assess the effect of the treatment on brain activity using a scan called magnetic resonance imaging (MRI).
Participants will receive compensation for completing the study.
IRB Approval # 7950
- Males and females between the ages of 18-55
- Current primary diagnosis of body dysmorphic disorder (BDD)
- History of intolerance or non-response to a prior adequate trial of an SSRI, SNRI, or clomipramine
- Current and severe major depressive disorder
- Current or past bipolar disorder, psychotic disorder, or borderline personality disorder
- Alcohol or drug use disorder in the past 3 months
- Current significant suicidality or a suicide attempt within the past year
- Body image concerns accounted for primarily by an eating disorder , or that are only weight-related
- Current cognitive-behavioral therapy specific for BDD
- Enrollment in any investigational drug or device study in the past 30 days
- Past negative effects from psilocybin