This study is investigating what, if any, changes in brain chemistry take place in adults with OCD as a result of cognitive behavioral therapy (CBT). We will measure amounts and distribution of glutamate in the brain using MRSI (Magnetic Resonance Spectroscopic Imaging) scans before and after 4 weeks of CBT.

The study offers:

  • Diagnostic evaluation
  • 4 weeks of FREE intensive CBT (exposure and response prevention): 90 minutes/day, 5 days/week
  • MRI/MRSI brain scans
  • Neurocognitive testing

UCLA Semel Institute
Principal Investigator
Jamie Feusner, MD; Joseph O'Neill, PhD
Eligibility Criteria
  • Have no history of bipolar disorder, a psychotic disorder, or substance dependence
  • Are in good physical health
  • Have not already had more than 30 hrs of CBT for OCD
  • Are right-handed
  • Between the ages of 18 and 65
  • Either not taking psychiatric medications or on a stable dose of a serotonin reuptake inhibitor (only) for at least 12 weeks
Courtney Sheen, 310-206-0468,
Los Angeles