This is a 14 week, placebo-controlled study testing the efficacy of propranolol treatment for PTSD. The rationale for this study is based on recent animal data suggesting that aversive memories are reconsolidated each time they are recalled, and that at those times, the memory can be strengthened or weakened by acute pharmalogical treatments, including beta-adrenergic receptor blockade.


We will ask subjects to take a dose of the beta-blocker propranolol (or placebo) each time they experience an intrusive memory. Only two doses may be taken per day, and the doses must be separated by 6 hours. Subjects must also keep a daily symptom diary. The trial lasts for 14 weeks and subjects may continue in their current psychotherapy. Subject cannot participate if they are taking antidepressants or daily benzodiazepines. They also cannot participate if they have asthma, heart disease, or diabetes.

New York Presbyterian Hospital/Weill Cornell Medical College
Principal Investigator
Margaret Altemus, MD
Eligibility Criteria

If you are between the ages of 18 and 60 and have PTSD, you may qualify for a free drug treatment research study.

The study will be 14 weeks in duration and will involve office visits every 2 weeks and keeping a daily symptom diary. You may receive the study drug or a placebo. There is no payment for participation.

Margaret Altemus, MD, 212-746-3751
New York, NY