Adults

A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD) (RELIANCE-II)

Eligibility Criteria

•    Adults 18 to 65 years, inclusive.
•    Meets DSM-5 criteria for major depressive disorder.
•    Currently experiencing a major depressive episode.
•    Has had an inadequate response to current ongoing treatment with an approved antidepressant.
 

Exclusion Criteria
  • Treatment-resistant depression.
  • History of bipolar I or II disorder.
  • Any psychiatric condition which takes a primary focus of treatment over MDD.
  • Significant or poorly controlled concomitant medical illness.
  • Alcohol or other substance use disorder.
  • Pregnant, breast-feeding or planning to become pregnant or breast-feed during the study.
  • Significant risk of suicide.
State
Alabama
California
Connecticut
Florida
Georgia
Idaho
Maryland
Nevada
New Jersey
New York
Ohio
Pennsylvania
Texas

This is an outpatient, 2-arm, Phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of REL-1017 once daily (QD) as an adjunctive treatment of Major Depressive Disorder. Study participants will continue to take their current antidepressant therapy in addition to the study drug or placebo for the duration of the treatment period.

IRB approval #: 20210876

by Jessica Wendi Abel
When I was 9-months pregnant with my second baby, I tried to find a children’s picture book to read with my nearly five-year-old about a family living with the most common condition after childbirth—postpartum depression—and was shocked to find no book like this in 2020. I set out to create a resource for the 1 in 7 women who will experience postpartum depression along with their families. 
by Olga Kavina
I work as a freelance illustrator. It is very difficult for me to fit into a team and I prefer to work from home and communicate only with close friends. I often feel lonely, sad and anxious, but drawing helps me. I put my feelings on paper. 

fMRI Response Inhibition Training Project

Eligibility Criteria

•    age between 18 and 60 
•    moderate level of OCRD symptoms 
•    a primary diagnosis of OCRD   
•    Estimated IQ > 80 
•    presence of a significant Response Inhibition deficits  
•    Access to a computer/laptop with high-speed internet and Google Chrome or a compatible web browser  
•    English as a primary language   
 

Exclusion Criteria

•    Current substance use disorder  
•    Severe ADHD 
•    Current psychotherapy or plans to engage in psychotherapy over the course of study participation 
•    Change in psychotropic medication status within 8 weeks before the study or during the study participation 
•    Use of stimulant medication, including the following: 

  • Ferrous metal or implants in body 
  • Braces or permanent retainer 
  • Pregnant 
  • History of neurological disorder or injury (e.g., seizures, migraines, tumor, chemotherapy, multiple sclerosis, movement disorder)  
  • Claustrophobia 
  • Unable to lie still for up to 2 hours 
  • Eye problems or difficulties with corrected vision (necessary for viewing tasks in scanner)

Our study is only for the US audience as there are some in person components in Milwaukee Wisconsin

State
Wisconsin

The UWM Anxiety Disorder Lab and the UWM Affective Neuroscience Lab are currently testing computer-based treatment programs designed to help adults (aged 18-60) suffering from problematic repetitive behaviors. This research is conducted by the University of Wisconsin-Milwaukee and is funded by the National Institutes of Mental Health.  Study procedures will be completed through at home computer-based training programs/assessments as well as assessments and brain imaging tasks at the Medical College of Wisconsin over the course of 8-15 weeks.  

by Waylon Griswold
I woke up that day in early September feeling okay at first but around 8am, I became very depressed for no reason I could say exactly. I told my mother (grandmother) that I was going to go for a walk, but I had another plan. There is a 15–20-foot lighthouse by a lake near where I live. It is a truly beautiful place but, on this day, it wasn't so beautiful. 
by Neal Sideman

I have chosen to focus on my healing, and to say only a few words about my long period of suffering. Chances are, you already know – firsthand or secondhand – more than you'd care  to know about the suffering! My own suffering had its unique form, but essentially, it was no different from what you probably already know.

by Melissa Lewis-Duarte, Ph.D.
Developed several decades ago by Michele McDonald, RAIN is a tool for practicing mindfulness when we feel overwhelmed by our thoughts and emotions. As someone who both lives with anxiety and practices mindfulness, I found this framework practical and implementable.