by Doug Duncan

Doug-Duncan-webcrop.jpgDepression can affect anyone — men, women, and children — at any point in their lives. And its debilitating effects show up in many different ways. Doug Duncan tells us how depression changed his life.

by Steven C. Hayes, PhD

What can we do to prosper when facing pain and suffering in our lives?

Pschologist Steven Hayes describes psychological flexibility in relation to his own harrowing panic disorder

by Rita Zoey Chin

Rita Zoey ChinThere was a time when basic things—like driving, climbing a flight of stairs, taking a shower, or going through the checkout line at the grocery store—landed me somewhere between mortal unease and full-throttle terror. It all began with a single panic attack that seemed to strike out of the blue. Mistaking it for a heart attack, I called an ambulance, but I quickly learned that there is no ambulance for an alarm of the mind.

by Felicia

It started at the onset of puberty, when I was 11 years old. I was at school, watching my older sister load the school bus to be taken away to 6th-grade camp. Suddenly a wave of panic overcame me. I don't recall my physical symptoms other than a racing heart and nausea.

by David H.

As a child, I was gregarious, outgoing, and happy-go-lucky. Then something went horribly askew at about age 12. I did not know why I was unable to focus when I had been the best reader in school. I had been talkative, but I kept to myself, remained silent, and let bullies pick on me. I hadn't the slightest idea what was going on with my body and mind. Eighth-grade was probably my worst year because I was taunted, harassed, and bullied.

by Jack Hagge

“Hi! I'm Jack. And I have an anxiety disorder.”

Merely talking to other people makes me anxious. I often experience "phone fear." I avoid social gatherings (particularly parties), which I find excruciating. Crowded settings, especially without a perceptible escape route, cause me uneasiness, sometimes panic.

by Melanie Higgins

I had all the typical life stressors of a married working mom. One spring I had a birth control device implanted that apparently threw my hormones and mental well-being out of whack. I switched to part-time work that summer because it allowed for a bit more rest and less stress. But when I returned to work full-time in the fall, I began having odd flashes of fear. And when people around me felt sick, I did, too.

by Cynthia Kipp

I have suffered from social anxiety disorder since I was about 10 years old, or about 34 years. I was a very intelligent child, but when teachers noticed a difference in me, I started trying to be invisible. Social situations, including school, were torture. I bulldozed my way through life, including dabbling in alcohol and substance abuse for relief of my anxiety and depression. I find it very interesting that the disorder is marked by a morbid fear of authority figures. And here I thought I was just being a rebel!

by K. Waheed

I am a middle-aged woman, married with two children. I was diagnosed with posttraumatic stress disorder (PTSD) at age 25. I am grateful to say that I have had tremendous support, terrific professional help, a strong will to recover, and a resolve to do whatever work necessary to overcome all of my trauma. Other miraculous help has been my spiritual beliefs and practices.

Trial of Centanafadine Efficacy and Safety as Monotherapy or as Adjunct to SSRI in Adults With Major Depressive Disorder (JUNIPER)

Eligibility Criteria
  • Minimum Age: 18 Years
  • Maximum Age: 65 Years
  • Sex: All
  • Gender Based: No
  • Accepts Healthy Volunteers: No
  • The trial population will consist of adult patients (18 to 65 years of age, inclusive) with a current primary diagnosis of MDD, single or recurrent episode, without psychotic features and do not meet criteria for MDD with mixed features subtype, who are in a current Major Depressive Episode (MDE) as defined by the DSM-5 criteria and confirmed by the SCID-5-CT.
  • All patients must have a score of ≥ 18 on the Hamilton Depression Rating Scale – 17 item (HAM-D17) and a rating of 4 or higher on the Clinical Global Impression – Severity (CGI-S) scale at screening and baseline. 
Exclusion Criteria
  • Patients who are not willing or are unable to discontinue all prohibited medications or who have started psychotherapy within the last 3 months will be excluded.
  • Patients who have been treated with electroconvulsive therapy or transcranial magnetic stimulation for depression, have had a vagus nerve stimulation or deep brain stimulation device implanted or have been treated in the past with ketamine, arketamine, or esketamine, will be excluded.

This is a phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-arm trial to assess the efficacy, safety, and tolerability of centanafadine
once-daily (QD) extended-release (XR) capsules for the treatment of adult subjects diagnosed with Major Depressive Disorder (MDD) who have reported